Mrs. Isabella Knudsen Mebane graduated from the College of Charleston in 1928. Because of her, Dr. Mebane loved and respected the College of Charleston. The chair was established in 1987 with a gift from Mrs. Mebane and alternated between the chemistry and physics departments with two year terms. It was the first endowed chair at the College of Charleston. In 1998 the Mebane Endowment had increased in value to where a chair could be sponsored in each department and the terms extended to four years in length.
Holders of the chair and their initial year of appointment are as follows:
1988 Marion T. Doig, III
1992 Elizabeth Martin
1996 Henry Donato, Jr.
2000 W. Frank Kinard
2004 Gary Asleson