CHEMISTRY 221 --- QUANTITATIVE ANALYSIS

DEPARTMENT OF CHEMISTRY & BIOCHEMISTRY
COLLEGE OF CHARLESTON

SYLLABUS

CHEMISTRY 221 --- QUANTITATIVE ANALYSIS

I. ANALYICAL CHEMISTRY AND ANALYTICAL DATA
A. Nature of Analytical Chemistry
B. Sampling
C. Concentrations
1. Molarity and molality
2. Percent composition
3. ppm and ppb

II. LABORATORY PROCEDURE AND GLASSWARE*
A. Lab Notebook
B. Burets
C. Volumetric Flasks
D. Pipets
E. Calibration
F. Sample preparation

III. EXPERIMENTAL ERROR
A. Significant Figures
B. Absolute and Relative Uncertainty
C. Precision and Accuracy
D. Errors

IV. STATISTICS
A. Frequency Distribution
B. Mean, Median, Mode
C. Scatter of Data
D. Confidence Limits
E. Q-test
F. Linear Regression
G. Calibration curves

V. OVERVIEW OF EQUILIBRIA
A. Equilibrium Constant
B. Le Chatelier's Principle
C. Solubilty
D. Acid-Base

1. Weak vs. strong
2. pH, pOH, [H+], [OH-], Ka, and Kb

VI. TITRATIONS*
A. Stoichiometry
B. Standardization
C. Analysis of Unknowns
D. Back Titrations
E. Titrations of Mixtures

VIII. INTRODUCTION TO SPECTROCHEMISTRY
A. Fundamental Concepts

1. Electromagnetic Radiation
2. Interaction of Radiation with Matter
3. Beer's Law
B. Atomic Absorption
1. Instrumentation
2. Applications
C. Ultraviolet and Visible Spectrophotometry
1. Instrumentation
2. Applications

IX. MONOPROTIC ACID-BASE
A. Strong Acids and Bases
B. Weak Acids and Bases

X. BUFFERS
A. Henderson-Hasselbach Equation
B. Preparation of Buffers

XI. ACID-BASE TITRATIONS
A. Tiitration of a Strong Acid with a Strong Base
B. Titration of a Strong Base with a Strong Acid
C. Titration of a Weak Acid with a Strong Base
D. Titration of a Weak Base with a Strong Acid
E. Indicators

XI. POLYPROTIC ACIDS AND BASES
A. Amino Acids
B. Diprotic Systems
C. Titrations

XIII. ELECTRODE POTENTIALS
A. Fundamental Concepts

1. Electrochemical Cells
2. Shorthand for Cells
3. Sign Conventions
4. Nernst Equation
5. Standard and Formal Potentials
6. Calculation of Equilibrium Constants
B. Reference Electrodes

XIV. ELECTRODE MEASUREMENTS
A. The Silver Indicator Electrode
B. Glass-Membrane Electrode
C. Ion-selective Electrodes

XV. EDTA AND IODINE TITRATIONS*
A. Metal-cchelate complexes
B. Indicators
C. Titrations

XVI. PRINCIPLES OF CHROMATOGRAPHY
A. Fundamental Concepts

1. Partition Ratios and Capacity Factors
2. Resolution
3. Theoretical Plates
B. Internal Standards

XVII. GAS AND LIQUID CHROMATOGRAPHY
A. Gas Chromatography
B. Classical Liquid Chromatography
C. High Performance Liquid Chromatography

XVIII. CHROMATOGRAPHY AND CAPILLARY ELECTROPHORESIS
A. Ion Exchange Chromatography
B. Ion Chromatography
C. Molecular Exclusion
D. Affinity Chromatography
E. Capillary Electrophoresis

XIX. GRAVIMETRIC AND COMBUSTION ANALYSIS*
A. Mechanism of Precipitation
B. Gravimetric Calculations
C. Combustion Analysis

XX. ATOMIC SPECTROSCOPY
A. Fundamentals
B. Atomization by Flames, Furnaces, and Plasmas
C. Temperature Effects
D. Instrumentation
E. Interferences
F. Standard Additions