March 22, 2006

Chapter 19 Amines and Amides

19.5 Heterocyclic Amines and Alkaloids

Heterocycle- contains at least one non-carbon atom in the ring

Alkaloid- physiologically active nitrogen-containing compounds produced by plants

Examples: nicotine, quiine, heroin

19.7 Hydrolysis of Amides

Acid hydrolysis

Base hydrolysis

SAR-the relationship between the chemical structure of a compound and its biological or pharmacological activity.

Compounds are often classed together because they have structural characteristics in common including:

shape

size

stereochemical arrangement

and distribution of functional groups

Other factors contributing to structure-activity relationship include:

chemical reactivity

electronic effects

resonance

and inductive effects.

Rational drug design of drugs is based on the premise that the biological properties of a compound are encoded in its molecular structure.

Homework:

19.3, 19.5, 19.7, 19.9, 19.11, 19.13, 19.15, 19.17, 19.19, 19.21, 19.23, 19.31, 19.33, 19.35, 19.37, 19.43, 19.47