March 24, 2006

Chapter 19 Amines and Amides

SAR-the relationship between the chemical structure of a compound and its biological or pharmacological activity.

Compounds are often classed together because they have structural characteristics in common including:

shape

size

stereochemical arrangement

and distribution of functional groups

Other factors contributing to structure-activity relationship include:

chemical reactivity

electronic effects

resonance

and inductive effects.

Rational drug design of drugs is based on the premise that the biological properties of a compound are encoded in its molecular structure.